Biography
William Song, M.D. is a resident physician in Internal Medicine at the Ochsner Clinic Foundation in New Orleans, Louisiana, United States. He completed his MD from the University of Queensland-Ochsner Clinical School in Brisbane, Australia, and New Orleans, Louisiana, USA. He is clinically interested in the fields of gastroenterology, oncology, and critical care medicine.
Introduction
Gastric cancer is the 5th most common type of malignancy world-wide. Obesity has been associated with an increased risk of gastric cancer and Roux-en-Y is the most commonly performed surgical weight-loss procedure in the US. Gastric adenocarcinoma in the remnant stomach after Roux-enY is rare, with only a few cases reported in literature [2,3,4]. We present a case of a gastric adenocarcinoma in the excluded stomach, 20 years after gastric bypass surgery.
A 50-year-old woman with a remote history of breast cancer and Roux-en-Y gastric bypass surgery who presented with five weeks of nausea, vomiting, constipation, abdominal pain and significant weight loss with inability to tolerate solid food. She developed ascites and bilateral pleural effusions. Thoracentesis and paracentesis showed non-cancerous cells. Her abdomen was globose, soft and massless with diffuse tenderness to palpation. Diagnostic laparoscopy and intraoperative esophagogastroduodenoscopy revealed intact post Roux-en-Y anatomy and no obvious cause for her symptoms. The procedure showed extensive peritoneal adhesions and diffuse small bowel inflammation. Spontaneous bacterial peritonitis secondary to extensive adhesions and inflammation was considered but her symptoms continued despite appropriate treatment. Subsequent CT abdomen revealed diffuse peritoneal carcinomatosis. Given her breast cancer history, there was concern for ovarian malignancy but transvaginal ultrasound revealed no adnexal masses. Her tumor markers CEA and CA-125 were elevated. Double balloon endoscopy was performed to evaluate for malignancy of a different origin and revealed an ulcerated pylorus as well as irregular appearing mucosa in the remnant stomach. Biopsies taken revealed poorly differentiated gastric adenocarcinoma, diagnosed as stage IV gastric adenocarcinoma with diffuse peritoneal carcinomatosis. Her symptoms remained intractable. She was transferred to an inpatient hospice facility closer to her home.
Although the development of cancer in the remnant stomach after gastric bypass is rare, it is important to consider the possibility particularly in patients with concerning symptoms such as extreme weight loss and constant abdominal pain. As more cases of post RYGB malignancies are reported, further research is
needed to clarify the association between gastric bypass and stomach cancer to keep potential bypass patients aware of all potential complications.
Keywords:
Gastric adenocarcinoma, Roux-en-Y, Gastric bypass surgery, Double balloon endoscopy